Pick Hono for
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Runtime portability
One codebase on Workers, Fastly, Deno, Bun, Node, Lambda, Vercel, and Netlify. Stacks runs on Bun today, with more runtimes planned, and does not deploy to edge platforms.
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Cold starts and size
For workers measured in kilobytes and milliseconds, Hono is in a category Stacks is not competing in.
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Type inference
The RPC client infers types from every route with no opt-in and no generation step. Stacks infers only from routes registered through its typed router.
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Simplicity
The whole framework can be read in an afternoon, which is worth a lot for a service you will maintain for years.