Pick Hono for
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Runtime portability
One codebase on Workers, Deno, Bun, Node, and Lambda. Stacks targets Bun and does not run at the edge.
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Cold starts and size
For workers measured in kilobytes and milliseconds, Hono is in a category Stacks is not competing in.
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Type inference
The typed client from route definitions is elegant and needs no generation step.
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Simplicity
The whole framework can be read in an afternoon, which is worth a lot for a service you will maintain for years.